Real Madrid now have 45 points from 19 matches, second behind defending champions Barcelona.
Manchester United bounced back from their defeat with a 4-1 win over Real Betis in the first leg of their Europa League last-16 tie.
Bologna advanced to the Europa League quarter-finals after a thrilling 4-3 win against AS Roma.
Arsenal sailed through the Europa League group stages, winning five of their six group matches and take on Sporting next, who overcame Denmark's FC Midtjylland in their playoff.
Swansea City have signed midfielder Alejandro Pozuelo from Real Betis on a three-year deal, the Premier League club said on Tuesday.
Aston Villa secured a 1-0 victory against Lille in the Europa League, while other matches saw Bologna draw with AS Roma and Porto win against VfB Stuttgart.
Atletico Madrid extended their unbeaten run in LaLiga to nine matches with a 2-0 victory over hosts Real Betis on Monday.
Stuttgart stumble to 1-1 against Union, miss out on top three
Barcelona stay on course to defend their Copa del Rey title with a 2-1 win over Albacete.
He made it 3-0 with a superb first-time finish into the bottom corner in the 20th minute, scoring his first ever treble in a competitive game, more than 19 years after making his professional debut.
Lyon sealed top spot in the Europa League standings while Roma survived a red-card scare to reach the last 16 on a chaotic final league-phase night.
Mbappe chasing Ronaldo record as Real Madrid host Celta
AS Roma took a big step towards qualifying for the Europa League last 16 with a 2-0 win over VfB Stuttgart on Thursday.
Adrien Rabiot scored two goals as AC Milan came from behind to earn a 3-1 victory at Como on Thursday.
Lyon thump Maccabi Tel Aviv to go top, Forest keep on winning
With a game in hand, Hansi Flick's Barca are top on 66 points, three ahead Real in second
The 23-year-old Palmer's two assists in five minutes during the second half turned the match around for Premier League club Chelsea and his efforts saw him named Player of the Match.
Aston Villa secured a 2-1 victory at Basel on Thursday, with goals from Evann Guessand and Youri Tielemans keeping their Europa League campaign on a strong footing.
Metz draw at Marseille to end losing streak
Vinicius Jr, who joined Real in 2018, has won the Spanish top-flight league three times with the club, apart from two Champions League and two Club World Cup titles.
Betis's Chimy Avila hit the post with an acrobatic volley one minute later and both teams wasted several chances for the winner late on.
Late goals from Dani Olmo and Robert Lewandowski earned LaLiga leaders Barcelona a hard-fought 2-0 victory over Espanyol.
Nottingham Forest handed manager Sean Dyche the perfect debut with a 2-0 home win over Porto in the Europa League on Thursday, with both goals coming from the penalty spot.
IMAGES from football matches played across Europe on Friday.
Juventus climb to top of Serie A with win over Lecce
Images from Saturday's La Liga action.
Nadal, a Real fan despite his uncle Miguel Angel making over 200 appearances for arch-rivals Barcelona, was seen speaking to umpire Mohamed Lahyani about his team's 0-0 home draw with Real Betis on Saturday and was less than impressed with what he saw.
Real Madrid suffered a shock 1-0 home defeat to Real Betis on Wednesday as an inspired performance from their former goalkeeper Antonio Adan and a stoppage-time winner from Antonio Sanabria stunned the Liga champions.
Barcelona returned to the top of the LaLiga table with a comfortable 4-0 home victory over 10-man Real Sociedad on Sunday.
Real Madrid moved to the top of the Primera Liga after goals from Robinho and Alvaro Mejia clinched them a 2-0 win over Real Betis.
Cole Palmer lives up to his nickname in a scorching Club World Cup final on Sunday, scoring twice in Chelsea's 3-0 win over Paris St Germain on another broiling day at MetLife Stadium.
David Beckham was sent off in the final minute of Real Madrid's 0-0 home draw with Real Betis
Cristiano Ronaldo netted his 31st and 32nd La Liga goals of the season to lift Real Madrid to a 3-2 comeback win at Real Betis on Saturday that stretched their lead over second-placed Barcelona to 13 points.
Atletico Madrid got in the mood for Tuesday's Champions League quarter-final with Barcelona by thrashing Real Betis 5-1 on Saturday, their biggest win of the season. A classy finish from Fernando Torres and a fortuitous strike from Atletico's top scorer Antoine Griezmann gave the home side a 2-0 lead at halftime. Substitute Angel Correa then made a big impression in the second period, laying on the third goal for Juanfran and the fourth by Griezmann before Thomas Partey rounded off the scoring for the home team. Ruben Castro netted for Betis in the 79th minute when he pounced on a rare error from Atletico goalkeeper Jan Oblak.
Real Madrid were dumped out of the King's Cup by Primera Liga strugglers Real Betis on the away goals rule after they were held to a 1-1 draw at the Bernabeu on Thursday.
A summary of Saturday's action in Ligue 1, LaLiga and Bundesliga.
Images from the Serie A and La Liga matches played on Saturday.
Girona thrash Osasuna for first win of the season
Two goals from Luis Diaz and one from Mohamed Salah helped Liverpool stroll to a 3-0 victory at Manchester United.
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